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doi: 10.1177/1535759719835676 108 WaddySPWardJBBecerraAZPowersTFwuCWWilliamsKLet al

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Notably, while mouse iTregs can be highly suppressive in vivo , human iTregs generated under similar conditions often fail to acquire full regulatory function, highlighting important species-specific differences ( 2.2 The functional antagonism between Th17 cells and Treg cells The functional antagonism between Th17 cells and Treg cells primarily manifests in their reciprocal interactions and regulatory mechanisms within the immune system