These released exosomes can then modulate immune response in other cells through a payload of inflammatory cytokines, like TNF-alpha, or through microRNA s that decrease inflammation.[ref] Mast cell release of exosomes has been shown to increase the formation of collagen in fibroblasts, which can lead to fibrosis (including pulmonary fibrosis, IPF)
J Cent Nerv Syst Dis 12:117957352096223 Allen RA, Gatalica Z, Knezetic J, Hatcher L, Vogel JS, Dunn ST (2007) A common 1317TC polymorphism in MTHFR can lead to erroneous 1298AC genotyping by PCR-RE and TaqMan Probe assays
2014;2014 doi: 10.1155/2014/626319
Hair Growth & Follicular Health Recent investigations indicate that GHK-Cu: Activates dermal papilla cells, the specialized cells at the base of hair follicles controlling growth phase (anagen) entry Reduces follicle sensitivity to DHT (dihydrotestosterone), the hormone primarily responsible for androgenetic alopecia Promotes angiogenesis to the scalp, increasing oxygen and nutrient delivery to follicles Suppresses inflammatory cytokines that contribute to follicle miniaturization Enhances hair density and thickness through collagen synthesis and follicular cell proliferation Safety Considerations The safety profile is well documented
