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KPV, by contrast, is a short tripeptide fragment derived from the alpha-melanocyte stimulating hormone sequence that retains key signaling properties of the parent melanocortin peptide, allowing researchers to investigate inflammatory signaling pathways and epithelial barrier biology in controlled laboratory systems

Animal studies were performed in keeping with the principles put forth by the Experimental Animals Management Committee

'Rosacea is a chronic, inflammatory skin condition that is characterised by hypersensitive skin, red rosy cheeks, pimples and pustules

The receptor was first incubated with the isolated G protein and, when applicable, the ligand (10 M) for 30 min in a 25 mM HEPES, 100 mM NaCl, 5 mM MgCl 2 , pH 7.5 buffer