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Because the risk of invasive melanoma is small, one option in very elderly patients with large lentigo maligna is to simply photograph and watch the lesion carefully, biopsying any areas suspicious of invasive disease because of clinical or dermoscopic change

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Notably however, pragmatic trials (vs RCTs) are more susceptible to real-world clinician and health system factors

Combination therapies (GLP1s + emerging drugs) are being used for unmet need including lean mass preservation, weight maintenance, and improved tolerance