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NADPH is important in recycling oxidized glutathione and provides the reducing power needed for protein-based antioxidant systems 49

However, the absolute risk remains modest in those without pre-existing gallbladder disease

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Two of the field-defining dihexa papers from the Journal of Pharmacology and Experimental Therapeutics were formally retracted in April 2025 for falsified and fabricated image data, with the retraction attributing the misconduct to Leen Kawas and James Harding (retraction record