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serotonin production emotional regulation stress tolerance cognitive flexibility repetitive patterns (as self-soothing) Traits commonly associated with undermethylation autism include: rigidity or insistence on sameness perfectionistic behavior high internal tension difficulty shifting attention anxiety or agitation during transitions Copper Overload Autism Emotional Intensity, Sensory Reactivity, and Poor Stress Tolerance Another major biochemical pattern identified in autism is copper overload , a condition in which there is too much unbound (free) copper circulating relative to ceruloplasmin, the protein that should bind and neutralize copper