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1 Introduction Vitamin B12, or cobalamin, is a water-soluble vitamin, that plays an essential role in cellular metabolism, particularly in DNA synthesis, methylation processes, and mitochondrial functions ( Lactobacillus spp ) (LeBlanc et al., 2013), which are also found in the gastrointestinal tract of herbivorous animals, where the synthesis of B12 occurs and the vitamin can be acquired in animal tissues

The bioavailability factor Not all GHK-CU reaches target tissues equally

Given these limitations in human studies, animal models have been extensively utilized to further investigate age-related changes in LC number and function

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