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FIGURE 1 UbiquitinProteasome System: A Complexed but Coordinated System The UPS is a highly controlled mechanism of protein degradation and turnover in cells, starting with monomeric ubiquitin, a small protein with a molecular mass of approximately 8 kDa ( The Proteasome as a Target for Cancer Therapy The 20S proteasome is a 700-kDa large complex formed by four stacked rings, two outer -rings and two inner -rings

Whether that stability translates to meaningful systemic circulation in humans is a question the published literature has not yet answered

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A half-life greater than 5 hours results in a stable signal, enabling batch processing of many plates at once using the GSH-Glo Assay