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Wintermute et al., Clinical Oral Investigations 2024 Clinical Oral Investigations 2024 Delayed centrifugation weakens the in vitro biological properties of platelet-rich fibrin membranes Design 18 healthy donors PRF centrifuged immediately (T-0) vs after 16 minutes delay (T-1T-6) Measured membrane weight/size, cell content, and gingival fibroblast gene expression exposed to PRF releasate Results Immediate centrifugation produced the largest PRF membranes

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Evidence suggests MRS is inadequate, however, and often yields inconsistent results across studies