The maintenance protocol (5 mg/week, cycled) is appropriate for longevity-focused use
[DOI] [PMC free article] [PubMed] [Google Scholar] 195.Gojkovic S., Krezic I., Vrdoljak B., Malekinusic D., Barisic I., Petrovic A., Horvat Pavlov K., Kolovrat M., Duzel A., Knezevic M., et al
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Of particular interest is the action of BPC-157 in the context of cardiac arrhythmias