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baumannii ) and Enterobacteriaceae are commonly associated with healthcare-associated infections (HAIs) and are increasingly becoming resistant to most antibiotics, making previously effective drugs less effective in managing such infections [22, 23, 39]

Additionally, pharmacologic agents such as shikonin (a PKM2 inhibitor) and dichloroacetate (a PDK1 inhibitor) have been shown to suppress TEC apoptosis and attenuate renal interstitial fibrosis (Wei et al., 2019)

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Potential renal stress markers reported in rodent studies at higher doses