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179,180 Nonetheless, through the integration of multi-omics analysis and validation both in vitro and in vivo in NSCLC, a recent study disclosed that intracellular lactate drives extracellular lipolysis and FFA release via non-histone lactylation of apolipoprotein C-II (APOC2), bringing about immunotherapy resistance
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In particular, while several studies suggest that -3 PUFA consumption has protective effects on the development of autoimmune thyroiditis [122], others demonstrate that exposure to pollutants (especially heavy metals) that contaminate fish is associated with an increased risk of autoimmunity and thyroid dysfunction [121,124,125,126]
For example, water at 4 m (13.1 ft) depth can hold about 40% more O2 than water at the surface[2]
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