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It can be argued that the possible hypoglycemic effect is due to concomitant use of other therapies that cause hypoglycemia (eg, sulphonylurea) and it was demonstrated in clinical trials studying a combination of a GLP-1 receptor agonist and a sulphonylurea that the risk of hypoglycemia was higher when compared to placebo

Interestingly, maternal OS biomarker levels were unaltered, perhaps due to varied conversion to toxic metabolites or lower maternal metabolic detoxification capacities, both of which can further result in continued OPC accumulation in the placental-fetal compartment, hampered efficacy of antioxidant systems, or altered repair mechanisms

Like any injection, there is some discomfort during the injection but it is minimal