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Drug resistance: still a daunting challenge to the successful treatment of AML

10.1167/iovs.63.4.27 69 WangL.ZhangL.NiuY.SitiaR.WangC

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11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses