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That said, tolerability is broadly similar across the three compounds: gastrointestinal adverse events dominate, and slow titration is the universal strategy for managing them

LCLT may help reduce exercise-induced muscle discomfort and support faster recovery between training sessions

282 These cytokines sensitize nociceptive neurons, leading to neuropathic pain, and promote neuronal damage through demyelination and axonal degeneration

These strategies are supported by studies in hepatocellular carcinoma (HCC), where dual immunotherapy (anti-PD-L1/CTLA-4) with molecular agents improved antitumor response in patients with otherwise limited options (160, 161)