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Prior pancreatitis, gallbladder disease, kidney problems, diabetic retinopathy, significant gastrointestinal symptoms, and use of insulin or sulfonylureas may require closer risk assessment rather than automatic exclusion

Underline the necessity for a pre-dose fasting condition (enough to have an empty stomach) and observing an additional fasting period of at least 30 min post-dose, along with avoiding pharmacological interactions to allow correct semaglutide absorption

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Li et al (380) used exercise training to intervene in MASLD, 3 times a week, each time lasting 3-4 times, lasting 40-60 min and the continuous intervention for 24 weeks, which could effectively improve the lipid metabolism level of patients with mild, moderate and severe MASLD, reduce blood glucose and improve the function of the liver