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During oxidative stress, Nrf2 translocates into the nucleus to regulate the transcription and expression of antioxidant response elements (ARE), activating the intracellular antioxidant enzyme system to eliminate excess ROS and bolster the cells antioxidant capacity ( The inflammatory response is intricately linked to redox balance, with ROS serving as key pro-inflammatory mediators

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Whole body metabolism of acetaminophen (click figure) Glutathione (GSH) is a tri-peptide made of cysteine, glutamate, and glycine

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