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f GM , f WM , and f CSF are the portions of water specifically attributed to GM, WM, and CSF, respectively 34

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According to the MHRA-approved Summary of Product Characteristics, the most frequently reported side effects include nausea (affecting approximately 40% of patients), vomiting, diarrhoea, constipation, dyspepsia (indigestion), and abdominal pain

Studies have shown that downregulating the PI3K/AKT/mTOR pathway can increase cellular sensitivity to ferroptosis by downregulating the expression of downstream factors such as GPX4, SREBP1, and SLC7A11 ( 2+ , ultimately alleviating SLI in mice (Zhou et al., 2024)