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The secondary objective was to investigate whether early iron therapy administration in non-anemic iron deficiency has beneficial outcomes compared to iron deficiency with anemia regarding developmental scores, laboratory outcomes, and growth

These proteins also caused an increase in lipid peroxidation, suggesting that gp120 and Tat played an important role in BBB disruption by induction of oxidative cellular stress in endothelial cells [26]

Nausea typically occurs during the first 4-8 weeks of treatment or following dose increases, with many patients experiencing gradual improvement as their body adjusts to the medication

Notably, depletion of microglia using the CSF1R antagonist PLX5622 attenuated stress-related transcriptional changes not only in microglia but also in leukocytes, endothelial cells, and astrocytes, underscoring the central role of microglia in orchestrating stress responses across multiple cell types