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Larger real-world data and longer follow-up remain lacking, so short-term data are encouraging but still limited for broad clinical guidance

Cuba: exploring the history of admixture and the genetic basis of pigmentation using autosomal and uniparental markers

However, more recent studies assessing the role of ferrous iron in the pathophysiology first in vitro [74, 75] and then in vivo [76, 77] provided evidence that after a toxic dose of APAP ferrous iron derived from lysosomes is taken up into mitochondria through a Ca 2+ uniporter and facilitates the MPTP opening and cell death