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Miraglia E, Visconti B, Bianchini D, Calvieri S, Giustini S

J., LeQuang, J

(PubMed) The same review warns that systemic administration (IV) may shift melanin production, altering skins natural photoprotection and potentially increasing the risk of UV-induced skin damage or cancer a risk especially relevant in sunny climates

Jimenez AG, Lalwani S, Cipolli W (2021) Effects of metformin, rapamycin, and resveratrol on cellular metabolism of canine primary fibroblast cells isolated from large and small breeds as they age