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Other interesting biologics under investigation include faecal microbiota transplant (tested in animal models), and umbilical cord mesenchymal stem cell (UCD-MSCs) therapy (Phase I/II), with previous studies demonstrating promising results, including a reported case of complete resolution of PCOS in a young woman after a single intravenous injection

Since the reduced precursors are hypothesized to synthesize NAD + through formation of NADH, administration of NRH and NMNH may offer an NAD + boosting avenue that is independent of both salvage and PreissHandler pathways, and is unaffected by the microbiome 58

Serious adverse events remain rare in clinical reporting

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