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In continuation selenium compounds in 2004 Back and co-workers reported for the first time that spirodioxyselenurane and its tellurium analogue exhibit very good antioxidant activity by mimicking the glutathione peroxidase (GPx) enzyme which protects the organism from oxidative damage by catalyzing the reduction of peroxides using thiol as the cofactor [47, 56]

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C57BL/6J DIR-knockout mice were generated in-house at Helmholtz Munich (Supplementary Information 1)