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These mechanisms make GLP-1 crucial for both glucose control and appetite regulation, making it a key target for therapeutic interventions in diabetes and obesity

Very low calorie diets below 800 calories daily should only be followed under medical supervision within a structured weight management programme, as unsupervised restriction can lead to nutritional deficiencies, muscle loss, gallstones, and electrolyte imbalances

This pattern matches what doctors see with lower doses of Wegovy

Glucose-Dependent Insulinotropic Peptide (GIP): The Twincretin Combination with GLP-1 Glucose-dependent insulinotropic polypeptide (GIP) is a 42 amino acid peptide which is synthesised and secreted from neuroendocrine K cells in the duodenum and jejunum in response to nutrient ingestion