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[ref][ref][ref] Homocysteine goes down the transsulfuration pathway to form cysteine: Another path that homocysteine can take is to be converted to cysteine through a two-step process in the transsulfuration pathway

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Additionally, it has been demonstrated that elevated TOS and OSI parameters may precede the development of hypothyroidism in autoimmune thyroiditis and may serve as indicators of thyroid cell injury (101103)