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This article explores the biological and lifestyle factors that contribute to sleep issues while on tirzepatidethe active ingredient in Zepbound

73,74 The anti-fibrotic effects of DPP4 inhibitors such as vildagliptin and sitagliptin have been demonstrated in a mouse model of bleomycin-induced skin fibrosis, characterized by improved dermal texture, reduced hydroxyproline content, and decreased myofibroblast deposition through the inhibition of TGF--induced ERK signaling

By neutralizing the oxidative stress that would otherwise break down these cellular connections, it supports the integrity of the gut barrier

Some researchers highlight this caution explicitly