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controls Rabbit wounds: GHK alone or combined with helium-neon laser improved wound contraction, boosted granulation tissue, increased antioxidant enzyme activity, and stimulated new blood vessel growth Diabetic rat models: PIC dressings with GHK showed higher glutathione and ascorbic acid levels, better epithelialization, and stronger fibroblast activation New Blood Vessel Formation Wounds cant heal without blood supply

These results underscore the pivotal involvement of VSMC ferroptosis in the development of AA and indicated that targeting ferroptosis could effectively mitigate pathological vascular remodeling, providing a promising therapeutic approach for AA prevention