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98 The classic triad of clinical features (Figure 2) are altered mental status (including anxiety, agitation, and confusion), autonomic nervous system overactivity (including diaphoresis, tachycardia, hyperthermia, hypertension, vomiting, and diarrhoea), and neuromuscular hyperactivity (muscle rigidity, hyperkinesis including myoclonus and tremor, hyperreflexia, and bilateral Babinski sign)

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