Aggrecan content is reduced, and collagen composition changes from type II to type I, which can lead to fissures appearing in the NP and potentially extending into the AF
The next, phase 1b clinical trial in adults with T2DM compared once weekly retatrutide (0.5, 1.5, 3, 3 mg starting dose increased to 6, 3 mg starting dose increased to 12 mg) versus placebo versus dulaglutide 1.5 mg over 12 weeks [63]
If you're younger than 30, I don't know why you'd want to augment growth hormone unless you and your doctor decide that there's a clinical need or some other urgent need to do so because you're already making a lot of growth hormone
Many healthy, active individuals use MOTS-C to maintain metabolic health, enhance performance, and promote healthy aging