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Patients Seeking Sustained, Proven Efficacy: With 72-week and 3-year data available from SURMOUNT-1, Tirzepatide offers a well-established track record of sustained results

Hence, we strongly encourage the adoption of GLP-1RA plus SGLT2i combination therapy in T2DM patients with uncontrolled metabolic risks, i.e., especially those who need to lose weight and/or control high blood pressure

35 ALA is an endogenous dithiol compound that has been shown to decrease oxidative stress

Therefore, the most accurate conclusion is balanced: GLP-1 receptor agonists can delay gastric emptying and may increase retained gastric contents in selected patients, but the absolute risk of clinically significant aspiration pneumonia remains uncertain and may be lower than initially feared in stable, asymptomatic patients