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The FDA has specifically warned about this distinction, noting that the salt form raises safety questions because it has not been studied in clinical trials

Second, as a stimulant, long-term use is generally avoided to prevent potential strain on the cardiovascular system and to minimize the risk of dependency

While the exact mechanisms are still being studied, this suggests the glucagon component may play a key role in counteracting metabolic slowdown and fatigue, making Reta especially interesting in long-term metabolic research