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During caloric restriction, with or without GLP-1 aids, the weight lost by patients is a mix of lean mass and fat mass
If dietary measures prove insufficient, pharmacological options such as acarbose may be considered under specialist supervision, with all medications used off-label for this indication in the UK
Supplementary Figure 8 (A, B) Cumulative data showing relative concentrations of decreased metabolites in the R vs A group
Complementary in vitro studies revealed that liraglutide exerted a dose-dependent inhibitory effect on the secretion of pro-inflammatory mediators, including interleukin 6 (IL-6), prostaglandin E2 (PGE2), and nitric oxide (NO), and suppressed the expression of inflammatory genes in chondrocytes and macrophages [45]
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