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Its five main mechanisms of action are as follows: (1) Increases the threshold for migraine attacks by activating different sites on the gamma-aminobutyric acid (GABA) receptors in brain neural tissue, decreasing neuronal excitability, boosting membrane hyperpolarization, and decreasing focal discharges

Drinking enough fluids, staying active and eating fibre-containing foods may help

First, providers should evaluate whether dose optimization is appropriate