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The serotonin-norepinephrine reuptake inhibitors (SNRIs) duloxetine and milnacipran, which are the other two medications FDA-approved for fibromyalgia, are recommended by all clinical guidelines

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After 2 months, the animals were subjected to X-ray and MRI

Some anecdotal reports suggest improved spontaneous arousal for 23 days post-dose, but controlled studies have not confirmed persistent effects beyond the 68 hour pharmacodynamic window.