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Additionally, the UPS contributes to treatment resistance by degrading apoptosis-promoting factors and enhancing pro-survival signaling pathways, such as NF-B and PI3K/AKT

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A 2020 review, Maternal Folic Acid Supplementation Mediates Offspring Health via DNA Methylation , summarizes evidence that maternal folic-acid exposure can influence offspring DNA methylation and may have both beneficial and adverse effects depending on dose, timing, baseline nutritional status and genetic susceptibility

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