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For sponsors and research partners operating internationally, staying aligned with the latest FDA directions is essential for designing high-quality, inspection-ready studies

PMID: 41934766 FEBS Lett The planar cell polarity protein Vangl2 interacts with the PDZ-domains of Scribble but not with a unique PDZ-like domain in Inturned

it demonstrated preclinical efficacy (80), progressed to first in human testing, and showed activity in Ras driven models, including combinational benefit with platinum therapy (81, 82)