Those engaging in physical activity, living in hot climates, or experiencing increased urination (common with hyperglycemia or SGLT2 inhibitor medications) require additional hydration beyond baseline recommendations
While niacinamide helps protect the skin barrier, hyaluronic acid is known for its powerful humectant properties and ability to retain up to 1,000 times its weight in water, intensely hydrating the epidermis and visibly plumping the skin
Semaglutide medications work by activating the GLP-1 receptor alone, while tirzepatide medications activate both the GLP-1 receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor, creating what is commonly described as a dual incretin mechanism
Balica M, Bostrom K, Shin V, Tillisch K, Demer LL