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Disclosures: Neuen reports receiving fees for travel support, advisory boards, scientific presentations and steering committee roles from Alexion, AstraZeneca, Bayer, Boehringer Ingelheim, Cambridge Healthcare Research, Cornerstone Medical Education, Janssen, the limbic, Medscape, Novo Nordisk and Travere Therapeutics, with all honoraria paid to The George Institute for Global Health

Although rare, tumor transformation of nevi to melanoma involves the clonal expansion of cells that acquire a selective growth advantage