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Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

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In some cases, especially at the beginning of treatment for a severe deficiency, injections might be given more frequently (e.g., daily or every other day) for a short period before transitioning to a maintenance schedule

A monthly schedule gives the body more time between exposures and may smooth the side-effect peaks across a full dosing cycle