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However, high doses may cause side effects such as nausea, vomiting, diarrhea, and constipation

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officinalis leaf extracts showed dose-dependent agonist activity against AhR activation which makes them a potential candidate for the prevention and treatment of skin diseases caused by Aryl hydrocarbon receptor (AhR) activation [321]

Palatin Technologies subsequently developed PT-141 (bremelanotide) as a more receptor-selective compound that preserved the CNS activity while attenuating peripheral melanocortin engagement