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Zhang et al (106) demonstrated that hyperactivation of the PI3K/AKT pathway contributes to the overproliferation of epithelial cells in endometriotic lesions, while endometriotic stromal cells lose the regulatory control over epithelial growth, as indicated by elevated AKT phosphorylation

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Although nanotherapy has many advantages, some problems remain: the complexity and heterogeneity of tumor biology lead to uncertainty about its efficacy, as the interaction of NPs with this biology is not yet clear, and challenges related to NP cost, chemical processes, manufacture, and control persist (172, 173)