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But their translation into routine practice necessitates rigorous evaluation of safety, durability of efficacy, and patient heterogeneity-factors that remain insufficiently addressed to date ( 4.1 Liver-selective THR agonists for metabolic and fibrotic correction Emerging pharmacological strategies have increasingly targeted THR signaling, particularly in the treatment of NASH and progressive MAFLD (158, 159)

10.1186/s12935-020-01689-8 149 YangZ.JiangY.XiaoY.QianL.JiangY.HuY.et al (2023b)