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Revised Date: January 18, 2023 Recommendations and Topics Scope Key Recommendations Background Epidemiology Patient Risk Factors Associated with B 12 Deficiency Patient Risk Factors Associated with Folate Deficiency Prevention Diagnosis Management Ongoing Care References Resources Appendix A: Dietary sources of cobalamin Scope This guideline covers the primary care investigation and management of cobalamin (vitamin B 12 or simply B 12 ) and folate deficiency in adults

2, 3 Recent studies have implicated abnormalities in systemic physiology that transcend organ specific dysfunction, at least in some children with ASD

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However, DPRA is not suitable for metallic compounds, because they may form bonds with the nucleophilic residues in histidine 20