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Weight loss is important, but clinicians may also consider A1C, blood pressure, lipids, cardiovascular risk, liver fat, tolerability, medication interactions, quality of life, and long-term maintenance

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Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system

Interestingly, GHK alone appeared to produce a comparable stimulatory action, while copper(II) ions in isolation may indicate no such activity, suggesting the tripeptide moiety may be the primary active component, possibly reforming complexes with trace copper present in the culture medium