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Previous metabolomic and transcriptomic study of Cotadutide (GLP-1R/GCGR dual agonist) in hepatic fibrosis identified its effects on pathways related to lipogenesis, fibrosis, and inflammation (20)

Deubiquitination of GPCRs can regulate their lysosomal sorting, recycling and plasma membrane expression and may play an important role in receptor recycling and resensitization (Figure 2) [87]

It is important to monitor for any potential side effects and discuss with your healthcare provider regularly

In addition to regulating blood sugar and lowering body weight in non-diabetic obese patients, tirzepatide can also lower liver fat and improve kidney outcomes (Heerspink et al., 2022)