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In a double-blind, randomized study, opens in a new tab, L-citrulline was shown to significantly increase plasma arginine levels and boost nitric oxide-dependent signaling more effectively than L-arginine

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1962), low vitamin B6 levels is often related to depletion in neurotransmitters such as dopamine, serotonin, and -aminobutyrate due to its biochemical role as cofactor (PLP) for decarboxylases that are involved in neurotransmitter synthesis (Dakshinamurti and Stephens 1969)