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The latest trials demonstrated weight loss of up to nearly 23 percent of starting body weight - positioning retatrutide as perhaps the most powerful weight loss drug yet developed for adults with heart disease or type 2 diabetes

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These GLP-1 receptor agonists work by mimicking the hormone glucagon-like peptide-1 to regulate appetite, digestion, and blood sugar, but may cause side effects like nausea, diarrhea, or constipation, which are typically mild and improve over time