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Johansen et al
They do this in several ways: They boost insulin release when blood sugar rises They reduce glucagon (a hormone that increases blood sugar) They slow down stomach emptying, which prevents blood sugar spikes after meals For people with type 2 diabetes, these effects can mean better control of blood sugar levels and lower A1C (a measure of average blood sugar over time)
Ex-4 relieved the leakage of the BBB while reduced levels of astrocyte-derived MCP-1, CXCL-1 MMP-9, and VEGF-A in ischemic areas after MCAO in rats (101)
It is a likely reason why the weight loss and liver fat numbers in trials look stronger than older single- or dual-pathway compounds
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