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But heres the thing: While some dietary supplements billed as nootropics have some promising science behind individual ingredients, experts largely agree that the use of nootropics by healthy individuals to boost brain health is concerning due to the lack of clinical evidence regarding their efficacy, safety, and social consequences, especially in long-term use (18)

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The aged-rat cohort showed improved Morris water maze performance with the same oral protocol, though with greater variability reflecting the heterogeneous baseline cognitive status of the aged-rat population