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Single 1-gram dose regimen: Overall, the most common adverse reactions in patients receiving a single-dose regimen of 1 gram of azithromycin were related to the gastrointestinal system and were more frequently reported than in patients receiving the multiple-dose regimen

Less common but serious: pancreatitis, gallbladder problems, acute kidney injury from dehydration, hypoglycemia (with other diabetes meds), worsening diabetic retinopathy, and rare severe allergic reactions

Thomas MK, Nikooienejad A, Bray R, Cui X, Wilson J, Duffin K, Milicevic Z, Haupt A, Robins DA

In research, we also see positive changes in the gut microbiome in people taking metformin, says Wenz